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Thakur, Veena Devi
- Compatibility Study of Ambroxol HCl Drug-Excipients by Using IR Spectroscopy
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Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 3 (2013), Pagination: 98-101Abstract
Compatibility must be established between the active ingredient and other excipients to produce a stable efficacious, attractive and safe product.
In this report FTIR studies were performed and major peaks were determined by the (FTIR-8400S Shimadzu, Japan) will show band shift and broadening compared to the spectra of pure drug. To study the interaction between AmbroxolHCl, selected excipients (sorbitol, mannitol, sucrose).IR spectra of Ambroxol hydrochloride bands were found at 1595-1545 cm-1 for aromatic C=C stretching, 3350-3250cm-1 for aromatic primary amine NH stretch, 3400-3345 cm-1 for intermolecular hydrogen bonded OH stretch and 700-600 cm-1 for C-Br stretching. This confirms the identity of Ambroxol hydrochloride.
Keywords
Compatibility Studies, Ambroxol HCL and Excipients
References
- Marini et al; “Drug Excipient Compatibility studies by Physico Chemical techniques”; Journal of Thermal Analysis of Colorimetry; Volume ;73;2003 .
- William Kemp, Organic Spectroscopy, Infrared Spectroscopy, 3rd Edn, Palgrave, New York: 43, (199).
- G. R. Chatwal, S. K. Anand, Instrumental methods of chemical analysis,: Ist Edn Himalaya publishing house, Mumbai2.502.43, (2002).
- Skoog, Holler and Nieman, Principles of instrumental analysis, 5th Edn, Sounders College Publishing, USA: 184, (1998).
- G. W. Ewing, Instrumental methods of chemical analysis, 5th Edn, McGraw-Hill International Editions, Singapore: 90,(1985).
- The preformulation study of Ambroxol HCl for formulation of medicated chewing gum
Abstract Views :310 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)
Source
Asian Journal of Research in Chemistry, Vol 6, No 9 (2013), Pagination: 868-870Abstract
The studies prior to the formulation are broadly known as preformulation studies and these studies should focus on those physicochemical properties of compounds that could affect drug performance and development of an efficacious and specific dosage form. The preformulation studies were carried out of Ambroxol HCl in terms of tests for identification (physical appearance, melting point and IR spectra), solubility profile and quantitative estimation of drug by considering formulation of medicated chewing gum (MCG).Keywords
Preformulation, Solubility, Quantitative, Melting Point, Medicated Chewing GumReferences
- Lachman L, Lieberman A H and Kanig L. Joseph, “The Theory and Practice of Industrial Pharmacy”, 3rd edition, Varghese Publishing House, Bombay, India, 1991, Pg no. 171-173.
- Raviolo MA, Briñón MC. Preformulation Studies of Zidovudine Derivatives: Acid Dissociation Constants, Differential Scanning Calorimetry, Thermogravimetry, X-Ray Powder Diffractometry and Aqueous Stability Studies. Sci Pharm. 2011 Sep; 79(3):479- 491.
- Parmar Vilcy William and Thosar Millind, A Comprehensive Review on Medicated Chewing Gum, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2012:3(2): 894-906.
- Rama Bukka et al, Preparation and evaluation of Intraoral Drug Delivery system for Rasagiline mesylate, International Journal of Pharmaceutical Sciences and Drug Research, 2010,2(4):294.
- Gavaskar B, Venkataramana D and Rao Y Madhusudan, “Medicated Chewing Gum A Novel Approach to improve Patient Compliance”, International Journal of Research in Pharmaceutical and Biome Sciences 2011:2:23-32.
- Naik Heema and Gupta Stuti, “Medicated Chewing Gum Updated Review”, International Journal of Pharmaceutical Research and Development, 2011:2: 66-76.
- “The Merc Index” An Encyclopedia of Chemicals, Drugs and Biologicals, 13th Edition, Published by Merck Research Laboratores, Division of Merc and Co INC Whitehouse Station, 2001, Page no. 983.
- Technical Monograph No.4, IDMA-APA Guideline, Pharmaceutical Preformulation Analytical Studies.
- Tripathi K.D, “Essential of Medical Pharmacology”, 6th Edition, Jaypee Brothers Medical Publishers Pvt Ltd, New Delhi, India, Reprint 2009, page no. 213-216.
- “Indian Pharmacopoeia”, Vol-2, Published by the Indian Pharmacopoeia Commission Ghaziabad, 2007, page no.701
- William Kemp, Organic Spectroscopy, Infrared Spectroscopy, 3rd Edn, PALGRAVE, New York: 43, (199).
- Development and Characterization of Medicated Chewing Gum Containing Ambroxol HCl for Treatment of Bronchitis
Abstract Views :175 |
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Authors
S. J. Daharwal
1,
Rajendra K. Jangade
2,
Veena Devi Thakur
2,
Shikha Srivastava
2,
Bhanu Pratap Sahu
2
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 5 (2013), Pagination: 295-299Abstract
Patient convenience and patient compliance-oriented research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which Medicated chewing gum delivery system is convenient, easy to administer - anywhere, anytime - and is pleasantly taste making it patient acceptable. It offers a wide range of advantages that make it an excellent alternative. Various characterization parameters like hardness, drug content, stability and drug release were studied and best formulation was chosen.Keywords
Chewing Gum, Stability, Innovative.- Designing and Optimization of Medicated Chewing Gum of Ambroxol HCl by Using 32 Factorial Design
Abstract Views :194 |
PDF Views:1
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
Source
Asian Journal of Pharmaceutical Research, Vol 3, No 3 (2013), Pagination: 118-120Abstract
The present work deals with optimization of designed MCG , so that the best possible set of parameters affecting result can be selected to get the desired output. In this report nine batches of formulations (F1-F9) prepared and studied. Two variables were selected for the formulations in which first was concentration of elastomer and other was concentration of softener. The mathematical models developed for all the dependent variables using statistical analysis software Design experts 8.0.1.Percent Drug release of various formulation F2, F5, F8 andF9 was found to be 95.31, 98.74, 88.18 and 91.74. The highest Percent of Drug release among all is of F5.Keywords
Optimization, Medicated Chewing Gum, Ambroxol HCl.- Designing and Optimization of Modified Dissolution Apparatus for Evaluation of Medicated Chewing Gum of Ambroxol HCl
Abstract Views :183 |
PDF Views:2
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN